Interleukin-11 stimulates multiple phases of erythropoiesis in vitro
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چکیده
منابع مشابه
Interleukin-11 stimulates multiple phases of erythropoiesis in vitro.
Interleukin-11 (IL-11), a pleiotropic cytokine originally isolated from a primate bone marrow stromal cell line, has been shown to stimulate T-cell-dependent B-cell maturation, megakaryopoiesis, and various stages of myeloid differentiation, but to inhibit adipogenesis. Because stromal cells are essential for the maintenance of early hematopoietic progenitor cells in long-term culture, we inves...
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We investigated the effect of recombinant human interleukin-11 (rhIL-11) on human megakaryocytopoiesis. Nonadherent and T-cell-depleted human bone marrow (BM) mononuclear cells were cultured in a serum-free agar culture system. rhIL-11 alone did not stimulate the growth of human megakaryocyte colonies. However, when rhIL-11 was combined with optimal or suboptimal doses of rhIL-3, the number and...
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The requirements of clonogenic cells of B cell-type chronic lymphocytic leukemia (B CLI) for interleukin 2 (II 2) were analyzed. Using the cells of five patients. we measured IL 2 receptor expression on the cell surface and the colonyforming abilities of the cells in response to IL 2. In four of the cases. significant percentages of the CLI cells expressed IL 2 membrane receptors (as assessed w...
متن کاملInterleukin 2 stimulates chronic lymphocytic leukemia colony formation in vitro.
The requirements of clonogenic cells of B cell-type chronic lymphocytic leukemia (B CLL) for interleukin 2 (IL 2) were analyzed. Using the cells of five patients, we measured IL 2 receptor expression on the cell surface and the colony-forming abilities of the cells in response to IL 2. In four of the cases, significant percentages of the CLL cells expressed IL 2 membrane receptors (as assessed ...
متن کاملRecombinant human interleukin-11 directly promotes megakaryocytopoiesis in vitro.
We have investigated the mechanism of action of the thrombopoietic cytokine, recombinant human interleukin-11 (rhIL-11), on megakaryocytopoiesis in vitro. We have shown that rhIL-11-induced murine and human megakaryocytopoiesis are not mediated by thrombopoietin (Tpo). Murine megakaryocytes (MKs) were produced from bone marrow (BM) mononuclear cells cultured with rhIL-11, IL-3, and a combinatio...
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ژورنال
عنوان ژورنال: Blood
سال: 1992
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v80.5.1218.1218